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  • Real-time
    PCR
  • CE-IVD
    marked

Anyplex™ II
HPV28 Detection

Simultaneous detection and identification of 28 HPV types (19 high-risk and 9 low-risk)

Anyplex™Ⅱ HPV28 Detection simultaneously detects, differentiates and quantifies 28 distinct HPV genotypes (19 high-risk and 9 low-risk) responsible for cervical cancer and/or sexually transmitted infections. Based on Seegene’s proprietary DPO™ and TOCE™ technologies, this multiplex assay performs on  real-time PCR instrument and provides high sensitivity and specificity genotyping information of infected 28 HPV types in a single reaction

Key Features and Benefits

  • Multiplex real-time PCR

    Detection and identification of 19 high-risk HPV and 9 low-risk HPV in a single reaction

  • Whole process validation

    Whole process validation from extraction to PCR by whole process control

  • Automatic data analyzer

    Automated data interpretation and LIS interlocking with Seegene Viewer

  • User-friendly workflow

    Convenient workflow using Seegene’s automated one platform

  • Quantitative analysis

    Quantitative analysis by cyclic-CMTA

  • Useful monitoring

    Useful tool for surveillance and infection control

  • UDG system

    Utilization of the UDG system to prevent carry-over contamination

  • Proper patient care

    Quick and proper treatment provided by accurate test results

  • Automatic data analyzer

    Automated data interpretation and LIS interlocking with Seegene Viewer

  • Analytes

    19 High-risk HPV types
    • Human Papillomavirus 16 (HPV 16)
    • Human Papillomavirus 18 (HPV 18)
    • Human Papillomavirus 26 (HPV 26)
    • Human Papillomavirus 31 (HPV 31)
    • Human Papillomavirus 33 (HPV 33)
    • Human Papillomavirus 35 (HPV 35)
    • Human Papillomavirus 39 (HPV 39)
    • Human Papillomavirus 45 (HPV 45)
    • Human Papillomavirus 51 (HPV 51)
    • Human Papillomavirus 52 (HPV 52)
    • Human Papillomavirus 53 (HPV 53)
    • Human Papillomavirus 56 (HPV 56)
    • Human Papillomavirus 58 (HPV 58)
    • Human Papillomavirus 59 (HPV 59)
    • Human Papillomavirus 66 (HPV 66)
    • Human Papillomavirus 68 (HPV 68)
    • Human Papillomavirus 69 (HPV 69)
    • Human Papillomavirus 73 (HPV 73)
    • Human Papillomavirus 82 (HPV 82)
    • Internal Control (IC)
  • 9 Low-risk HPV types
    • Human Papillomavirus 11 (HPV 11)
    • Human Papillomavirus 40 (HPV 40)
    • Human Papillomavirus 42 (HPV 42)
    • Human Papillomavirus 43 (HPV 43)
    • Human Papillomavirus 44 (HPV 44)
    • Human Papillomavirus 54 (HPV 54)
    • Human Papillomavirus 6 (HPV 6)
    • Human Papillomavirus 61 (HPV 61)
    • Human Papillomavirus 70 (HPV 70)
    • Internal Control (IC)
  • Specimens

    • Liquid based cytology (e.g., ThinPrep® and Surepath™)
    • Cervical swab
  • Ordering Information

    Product
    Cat No. / Size
    Anyplex™ II HPV28 Detection
    HP10379Z / 25 rxns [1]
    HP7S00X / 100 rxns

Result

The result represents co-infection that HPV 16 is high (+++) in the HEX channel, HPV 52 is high(+++) in the Cal Red 610 channel, HPV 35, 61 are high (+++) in the Quasar 670 channel and HPV 40 is intermediate (++) in the Quasar 705 channel .

Publication

- Safety and acceptability of human papillomavirus testing of self-collected specimens: A methodologic study of the impact of collection devices and HPV assays on sensitivity for cervical cancer and high-grade lesions

- Effectiveness of bivalent and quadrivalent human papillomavirus vaccination in Luxembourg

- Continuing global improvement in human papillomavirus DNA genotyping services: The 2013 and 2014 HPV LabNet international proficiency studies

- Risk factors for type-specific persistence of high-risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment

- A single dose of quadrivalent human papillomavirus (HPV) vaccine is immunogenic and reduces HPV detection rates in young women in Mongolia, six years after vaccination

- Prevalence of human papilloma virus in Oman: Genotypes 82 and 68 are dominating

- Oral-genital human papillomavirus infection in Polish couples: frequent detection of HPV 42

- Strategic significance of low viral load of human papillomavirus in uterine cervical cytology specimens

- Women with Cervical High-Risk Human Papillomavirus: Be aware of Your Anus! The ANGY Cross-Sectional Clinical Study

- Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women

- HPV screening in the urine of transpeople – A prevalence study

- Impact of nucleic acid extraction procedures on human papillomavirus (HPV) detection and genotyping

- Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy

- Comparison between the Roche cobas 4800 Human Papillomavirus (HPV), Abbott RealTime High-Risk HPV, Seegene Anyplex II HPV28, and Novel Seegene Allplex II HPV28 Assays for High-Risk HPV Detection and Genotyping in Mocked Self-Samples

- Human papillomavirus prevalence and associated factors in indigenous women in Ecuador: A cross-sectional analytical study

- Prevalence and risk factors of anal human papillomavirus infections among men having sex with men and transgender women in Phnom Penh, Cambodia

- Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy

- Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis

- Human papillomavirus genotype distribution by cytological status and associated risk factors in the general population of Congolese women living in urban and rural areas: Implications for cervical cancer prevention

- Detection of HPV DNA in vaginal samples self-collected by women living with HIV treated through the Brazilian public health system: Prevalence and analysis of risk factors

- Prevalence and Risk Factors for High-Risk Human Papillomavirus Infection and Cervical Disorders: Baseline Findings From an Human Papillomavirus Cohort Study

- Comparative performance of Anyplex II HPV28 and Cobas 4800 HPV assays for high-risk HPV detection in self-collected anal samples

- Development of a touchdown droplet digital PCR assay for the detection and quantitation of human papillomavirus 16 and 18 from self-collected anal samples

- HPV Molecular Genotyping as a Differential Diagnosis Tool in Cervical Cancer Metastasis

- Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy

Note

[1]