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  • Conventional
    PCR
  • Research
    Use Only

Seeplex®
H. pylori-ClaR ACE Detection

Detection of two mutations (A2143G and A2142G) causing clarithromycin-resistance

Seeplex® H. pylori-ClaR ACE Detection simultaneously detects and identifies two types of point mutations (A2143G and A2142G) causing clarithromycin-resistance in Helicobacter pylori from direct examination of gastric biopsy tissue without going through bacterial culture. Based on DPO™ technology, this assays performs on PCR instruments and applicable for Auto-capillary Electrophoresis instruments.

Key Features and Benefits

  • Multiplex PCR

    Simultaneous identification of H. pylori and two point mutations (A2143G & A2142G), which cause clarithromycin resistance without culture

  • Prediction of antibiotic resistance

    Detection and identification of mutations associated antibiotic resistance for appropriate infection control

  • Powerful performance with unique technology

    Multiplex PCR with high sensitivity and specificity by utilization of DPO™ technologies

  • Reduction Contamination risk

    A single round PCR process and 8-MOP reduces the carryover contamination risk

  • Analytes

    Seeplex®
    H. pylori-ClaR ACE Detection

    • A2142G
    • A2143G
    • Helicobacter pylori (H. pylori)
    • Internal Control (IC)

  • Specimen

    • Gastric biopsy

  • Ordering Information

    Product
    Cat No. / Size
    Seeplex® H. pylori-ClaR ACE Detection

Result

IDResult
1H. pylori
2H. pylori, A2143G
3H. pylori
4H. pylori, A2143G
5H. pylori, A2142G
6H. pylori, A2143G
7H. pylori, A2142G
8H. pylori

1~8: Clinical samples

Publication

- Usefulness of Dual Priming Oligonucleotide-Polymerase Chain Reaction for Diagnosis and Treatment of Helicobacter pylori

- Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing

- Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection

- Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance

- Clarithromycin-resistant Helicobacter pylori associated with 23S rRNA point mutations in Jeju Island

- DPO multiplex PCR as an alternative to culture and susceptibility testing to detect Helicobacter pylori and its resistance to clarithromycin.

- A comparison analysis on the diagnosis of Helicobacter pylori infection and the detection of clarithromycin resistance according to biopsy sites

- Dual-Priming Oligonucleotide-Based Multiplex PCR for the Detection of Helicobacter pylori and Determination of Clarithromycin Resistance with Gastric B