Enterococci are normally indigenous bacteria found in the GI tract and female genitals, but recently they are recognized as major pathogens causing urinary tract infections and sepsis by nosocomial infection.
Vancomycin, which is used in the treatment of enterococci infection, is a drug that has an antibacterial effect by forming a complex with the D-alanyl-D-alanine terminal of the peptidoglycan precursor to block transglycosylation and transpeptidation during the synthesis of the cell wall of Gram-positive cocci. However, vancomycin-resistant enterococci (VRE) tends to multiply rapidly due to the high frequency and continuous
use of vancomycin.
The Seeplex® VRE ACE Detection is a PCR method that incorporates DPO™ technology with high sensitivity and specificity, and is a product that can test for the vancomycin- resistant vanA gene and the vanB gene of enterococci in one test.