Seeplex® H. pylori-ClaR ACE Detection

Detection of two mutations causing clarithromycin-resistance

  • ACE


Helicobacter Pylori, a major cause of chronic gastritis, is strongly associated with the development of gastric and duodenal ulcers and has been linked with gastric adenocarcinoma and B-cell mucosa-associated lymphoid tissue lymphoma. Current treatment of H. pylori infection consists of a triple or quadruple regimen that includes antibiotics and a proton inhibitor, such as amoxicillin and clarithromycin. Among these, the presence of clarithromycin-resistant H. pylori has been found, which has presented a serious obstacle to the treatment of H. pylori using clarithromycin. Thus, the detection of clarithromycin-resistant H. pylori is needed to increase the efficiency of the treatment and to prescribe other antibiotics by diagnosing the presence of clarithromycin-resistant H. pylori before treatment with antibiotics. Most clarithromycin- resistant H. pylori have point mutation at the 2142 and 2143 base sequences of the 23S rRNA gene, and exist as A2142G and A2143G, respectively.
Seeplex® H. pylori-ClaR ACE Detection is developed to detect these two kinds of point mutations specifically using DPO™ technology.


  1. Direct examination of gastric biopsy tissue without going through bacterial culture
  2. Simultaneous identification of H. pylori and two point mutations (A2143G & A2142G), which cause clarithromycin resistance without culture
  3. Applicable for Auto-capillary Electrophoresis instruments
  4. A single round PCR process reduces the carryover contamination risk, and 8-MOP, which is included in product, eliminates the contamination risk from PCR products
  5. Accurate system for result interpretation included Internal Control and Positive Control


- H. pylori - A2142G
- A2143G


- Gastric biopsy

Compatible Instruments

Result Preview

ID Result
1 H. pylori
2 H. pylori, A2143G
3 H. pylori
4 H. pylori, A2143G
5 H. pylori, A2142G
6 H. pylori, A2143G
7 H. pylori, A2142G
8 H. pylori
1~8: Clinical samples

Ordering Information

Product Cat. No. Size
Seeplex® H. pylori-ClaR ACE Detection HC1210Z 25 rxns

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ACE : Automatic capillary electrophoresis
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