Seeplex®ApoE ACE Genotyping

Apolipoprotein E (ApoE) ACE Genotyping

  • ACE
NOT AVAILABLE IN THE US

Outline

Apolipoprotein E (ApoE) plays a major role in the metabolism of plasma lipoproteins. There are three common isoforms (E2, E3, and E4) of ApoE protein and these isoforms differ in one amino acid sequence, an Arg (CGC) or Cys (TGC) at residue 112 and 158. The three isoforms arise from three alleles (E2, E3, and E4) which are combined in six different genotypes (homozygous genotypes: E2/E2, E3/E3, E4/E4, heterozygous genotypes: E2/E3, E2/E4, E3/E4). These genotypes are known to be associated with the risk of developing cardiovascular diseases and Alzheimer diseases. The ApoE4 protein has been reported as one of major risk factors for Alzheimer's diseases and coronary artery diseases. The ApoE2 protein is known to be protective for Alzheimer's diseases, but associated with type III hyperlipoproteinnemia. Therefore, determining the genotype of ApoE is considered to be an important test for healthy people on the aspect of precautions as well as patients with the diseases.

Features

  1. Test for six Apolipoprotein E (ApoE) genotypes with single PCR reaction.
  2. Multiplex PCR with high sensitivity and specificity by applying DPO™ (Dual Priming Oligonucleotide) technology
  3. Applicable for Auto-capillary Electrophoresis instruments
  4. A single round PCR process reduces the carryover contamination risk, and 8-MOP, which is included in product, eliminates the contamination risk from PCR products
  5. Accurate system for result interpretation included Internal Control and Positive Control

Analytes

- ApoE genotypes (SNP in codon112 and codon158)

Specimens

- Whold blood

Compatible Instruments

Result Preview

ID Result
1 E4/E4
2 E2/E4
3 E2/E3
4 E2/E4
5 E3/E3
6 E3/E4
7 E2/E2
1~7: Clinical samples, 8: Negative Control

Ordering Information

Product Cat. No. Size
Seeplex® ApoE ACE Genotyping AP1210Z 25 rxns

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ACE : Automatic capillary electrophoresis
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