Allplex™ H. pylori & ClariR Assay

Simultaneous detection and identification of
Helicobacter pylori and 3 major mutations
causing clarithromycin-resistance using multiplex real-time PCR

  • CE IVD


The prevalence of Helicobacter pylori (H. pylori) infection varies greatly among countries. In developing countries, it is over 70% while industrialized nations show prevalent from 20% to 50%1). Infection with H. pylori is considered a major cause of chronic gastritis and peptic ulcer disease2) and it is correlated with stomach cancer.
The “Triple Therapy” is first-line eradication therapy, which consists of a combination of Amoxicillin, Clarithromycin and a proton pump inhibitor3). However, clarithromycin resistance is increasing worldwide, and it has been considered as the main factor reducing about 30% of efficacy of H. pylori therapy4).

Allplex™ H. pylori & ClariR Assay is a multiplex real-time PCR assay that detects and identifies H. pylori and the most frequent point mutations (A2142G, A2143G and A2142C) responsible for clarithromycin resistance within the H. pylori 23S rRNA gene.

1) Liu Z, et al. BMC Microbiol. 2008;8:81
2) Cameron EA, et al. J Med Microbiol. 2004;53:535–8.
3) Glocker E, et al. Antimicrob. Agents Chemother. 2007, 51(1): 346-349
4) O’Connor A. Helicobacter 15 (Suppl. 1): 46–52


  1. Simultaneous detection and identification of H. pylori and major mutations
    (A2142G, A2143G, A2142C) responsible for clarithromycin resistance
  2. Cost-effective diagnostic test :
    Allows detection of H.pylori infection and clarithromycin resistance in a single test
  3. Typing for each mutation type
  4. Only 4 hours from extraction to the final results
  5. Automated data interpretation with Seegene Viewer


- H. pylori
- Internal Control (IC)
- A2142G
- A2143G
- A2142C


- Gastric biopsy specimen* - Stool
* Automated PCR setup only

Result Preview

The result represents the infection of H.pylori with A2143G mutation in FAM and CalRed 610 channels with Ct values of 29.83 and 28.91 respectively. Allplex™ H.pylori & ClariR Assay is able to provide the information of H.pylori and mutations causing clarithromycin resistance by analyzing individual Ct value using Seegene Viewer.

Ordering Information

Product Cat. No. Size
Allplex™ H. pylori & ClariR Assay HC10200Y
50 rxns
100 rxns*
'* ': For use with Microlab NIMBUS IVD & STARlet IVD only.

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Real-time : Real-time PCR
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